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Extracellular vesicles from deciduous pulp stem cells recover bone loss by regulating telomerase activity in an osteoporosis mouse model

Abstract Background Systemic transplantation of stem cells from human exfoliated deciduous teeth (SHED) recovers bone loss in animal models of osteoporosis; however, the mechanisms underlying this remain unclear. Here, we hypothesized that trophic factors within SHED-releasing extracellular vesicles...

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Glavni autori: Soichiro Sonoda, Sara Murata, Kento Nishida, Hiroki Kato, Norihisa Uehara, Yukari N. Kyumoto, Haruyoshi Yamaza, Ichiro Takahashi, Toshio Kukita, Takayoshi Yamaza
Format: Artigo
Jezik:Inglês
Izdano: BMC 2020-07-01
Serija:Stem Cell Research & Therapy
Teme:
Human deciduous pulp stem cells
Extracellular vesicles
MicroRNA
Telomerase activity
Osteoporosis
Online pristup:http://link.springer.com/article/10.1186/s13287-020-01818-0
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