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High-Throughput Drug Stability Assessment via Biomimetic Metalloporphyrin-Catalyzed Reactions Using Laser-Assisted Rapid Evaporative Ionization Mass Spectrometry (LA-REIMS)

<b>Background:</b> Building extensive drug candidate libraries as early in the development pipeline as possible, with high-throughput in vitro absorption, distribution, metabolism, and excretion (ADME) profiling, is crucial for the selection of lead compounds to guide subsequent research and product...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: András Marton, Zsombor Mohácsi, Balázs Decsi, Balázs Csillag, Júlia Balog, Richard Schäffer, Tamás Karancsi, György Tibor Balogh
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2024-09-01
Schriftenreihe:Pharmaceutics
Schlagworte:
high-throughput screening
metabolic stability
ambient mass spectrometry
LA-REIMS
biomimetic metalloporphyrin
lead profiling
Online-Zugang:https://www.mdpi.com/1999-4923/16/10/1266
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