New benzimidazole-alkanesulfonate conjugates as cholinesterase inhibitors with in vitro and in silico validation

Abstract Alzheimer’s disease, the leading cause of dementia, is strongly associated with impaired cholinergic neurotransmission due to excessive acetylcholine degradation by acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Because current medications provide only symptomatic relief with...

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Bibliografiska uppgifter

Huvudupphov:	Mohamed A. Omar, Aisha A. K. Al-Ashmawy, Hayam A. Abd El Salam, Riham A. El-Shiekh, Wael Mahmoud Aboulthana, Aladdin M. Srour
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Nature Portfolio 2026-03-01
Serie:	Scientific Reports
Ämnen:	Alzheimer Benzimidazole Alkanesulfonate Acetylcholinesterase Butyrylcholinesterase Antioxidant
Länkar:	https://doi.org/10.1038/s41598-026-39534-z
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