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Calcineurin/NFATc1 pathway represses cellular cytotoxicity by modulating histone H3 expression

Abstract Excess amounts of histones in the cell induce mitotic chromosome loss and genomic instability, and are therefore detrimental to cell survival. In yeast, excess histones are degraded by the proteasome mediated via the DNA damage response factor Rad53. Histone expression, therefore, is tightl...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Yuki Sato, Makoto Habara, Shunsuke Hanaki, Jafar Sharif, Haruki Tomiyasu, Yosei Miki, Midori Shimada
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Nature Portfolio 2024-06-01
Rangatū:Scientific Reports
Ngā marau:
Urunga tuihono:https://doi.org/10.1038/s41598-024-65769-9
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