Structural Insights Into the Transcriptional Regulation of HigBA Toxin–Antitoxin System by Antitoxin HigA in Pseudomonas aeruginosa

HigB-HigA is a bacterial toxin–antitoxin (TA) system in which the antitoxin HigA can mask the endoribonuclease activity of toxin HigB and repress the transcription of the TA operon by binding to its own promoter region. The opportunistic pathogen Pseudomonas aeruginosa HigBA (PaHigBA) is closely ass...

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Principais autores:	Ying Liu, Zengqiang Gao, Guangfeng Liu, Zhi Geng, Yuhui Dong, Heng Zhang
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2020-01-01
Serija:	Frontiers in Microbiology
Teme:	toxin–antitoxin system HigB-HigA transcription regulator crystal structure DNA-binding protein
Online dostop:	https://www.frontiersin.org/article/10.3389/fmicb.2019.03158/full
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