Selenylated Imidazo[1,2<i>-a</i>]pyridine Induces Cell Senescence and Oxidative Stress in Chronic Myeloid Leukemia Cells

Imidazo[1,2<i>-a</i>]pyridines (IPs) have been studied regarding drug development. The objective of this work was to evaluate the antileukemic capacity of IP derivatives by screening their ability as a pro-oxidant. IP derivatives were synthesized and oral bioavailability and toxicity were analyzed i...

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Autori principali:	Gabriella Teles Burkner, Dhébora Albuquerque Dias, Kamylla Fernanda Souza de Souza, Anna Júlia Papa de Araújo, Denise Caroline Luiz Soares Basilio, Fernanda Tondello Jacobsen, Ana Carolina Rabello de Moraes, Saulo Euclides Silva-Filho, Marcos Filipe de Oliveira Cavalcante, Cassio Augusto de Oliveira Moraes, Sumbal Saba, Maria Lígia Rodrigues Macedo, Edgar Julian Paredes-Gamero, Jamal Rafique, Eduardo Benedetti Parisotto
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2023-01-01
Serie:	Molecules
Soggetti:	leukemia imidazo[1,2<i>-a</i>]pyridines selenide oxidative stress senescence chronic myeloid leukemia
Accesso online:	https://www.mdpi.com/1420-3049/28/2/893
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