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Microglia-containing neural organoids as brain microphysiological systems for long-term culture

Microglia, essential for brain development, homeostasis, and neuroinflammation, originate from the yolk sac during embryogenesis and migrate into the developing brain. Because of this developmental origin, many brain organoid models naturally lack microglia and require co-culture. To address this is...

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Bibliografiska uppgifter
Huvudupphov: Alex Rittenhouse, Caroline Krall, Jesse Plotkin, Dowlette-Mary Alam El Din, Breanne Kincaid, Jason Laird, Lena Smirnova
Materialtyp: Artigo
Språk:Inglês
Utgiven: Frontiers Media S.A. 2025-10-01
Serie:Frontiers in Cellular Neuroscience
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Länkar:https://www.frontiersin.org/articles/10.3389/fncel.2025.1616470/full
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