A rapid method to reduce drug interferences for antibody measurements in pegunigalsidase alfa-treated patients with Fabry disease

AimNeutralizing anti-drug antibodies (ADA) limit therapy efficacies significantly. Pegunigalsidase alfa is a newly approved drug for the treatment of Fabry disease. The increased plasma half-life due to PEGylation interferes with ADA measurements including ELISAs and serum-mediated inhibition assays...

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Váldodahkkit:	Malte Lenders, Elisa Rudolph, Michael Rudnicki, Markus Cybulla, Eva Brand
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Frontiers Media S.A. 2026-01-01
Ráidu:	Frontiers in Immunology
Fáttát:	anti-drug antibodies drug interferences enzyme replacement therapy Fabry disease pharmacokinetics
Liŋkkat:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1724835/full
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