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Rapid Generation of Ventral Spinal Cord-like Astrocytes from Human iPSCs for Modeling Non-Cell Autonomous Mechanisms of Lower Motor Neuron Disease

Astrocytes play important roles in the function and survival of neuronal cells. Dysfunctions of astrocytes are associated with numerous disorders and diseases of the nervous system, including motor neuron diseases such as amyotrophic lateral sclerosis (ALS). Human-induced pluripotent stem cell (iPSC...

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Principais autores: Vincent Soubannier, Mathilde Chaineau, Lale Gursu, Ghazal Haghi, Anna Kristyna Franco Flores, Guy Rouleau, Thomas M. Durcan, Stefano Stifani
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-01-01
Serier:Cells
Fag:
amyotrophic lateral sclerosis
astrocyte
human-induced pluripotent stem cells
lower motor neuron
spinal cord
Online adgang:https://www.mdpi.com/2073-4409/11/3/399
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