Identification of prostate cancer potential therapeutic targets and virtual drug screening through combined Mendelian randomization study, Bayesian colocalization and molecular docking

Abstract Background Prostate cancer (PCa) faces significant global challenges, including rising incidence and drug resistance. Our research aims to identify novel protein targets for innovative treatments, evaluate potential adverse effects, and find compounds with strong binding affinity. Methods W...

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Principais autores:	Zilong Liang, Conglei Hu, Haofeng Pang, Yongxiang Shao, Lingchen Kong, Meng Cheng, Haiyang Du, Tianxi Feng, Zudu Fan, Liping Yao, Fei Liu
Format:	Artigo
Jezik:	Inglês
Izdano:	Springer 2025-06-01
Serija:	Discover Oncology
Teme:	Prostate cancer Therapeutic targets proteome-wide Mendelian randomization Bayesian colocalization Molecular docking
Online dostop:	https://doi.org/10.1007/s12672-025-02968-4
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