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The Thiazole-5-Carboxamide GPS491 Inhibits HIV-1, Adenovirus, and Coronavirus Replication by Altering RNA Processing/Accumulation

Medicinal chemistry optimization of a previously described stilbene inhibitor of HIV-1, 5350150 (2-(2-(5-nitro-2-thienyl)vinyl)quinoline), led to the identification of the thiazole-5-carboxamide derivative (GPS491), which retained potent anti-HIV-1 activity with reduced toxicity. In this report, we...

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Wedi'i Gadw mewn:
Prif Awduron: Subha Dahal, Ran Cheng, Peter K. Cheung, Terek Been, Ramy Malty, Melissa Geng, Sarah Manianis, Lulzim Shkreta, Shahrazad Jahanshahi, Johanne Toutant, Rose Chan, Sean Park, Mark A. Brockman, Mohan Babu, Samira Mubareka, Karen Mossman, Arinjay Banerjee, Scott Gray-Owen, Martha Brown, Walid A. Houry, Benoit Chabot, David Grierson, Alan Cochrane
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI AG 2021-12-01
Cyfres:Viruses
Pynciau:
HIV-1
adenovirus
coronavirus
RNA processing
inhibitor
Mynediad Ar-lein:https://www.mdpi.com/1999-4915/14/1/60
Tagiau: Ychwanegu Tag
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