Genetic and Real-World Clinical Data, Combined with Empirical Validation, Nominate Jak-Stat Signaling as a Target for Alzheimer’s Disease Therapeutic Development

As genome-wide association studies (GWAS) have grown in size, the number of genetic variants that have been associated per disease has correspondingly increased. Despite this increase in the number of single-nucleotide polymorphisms (SNPs) identified per disease, their biological interpretation has...

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Principais autores:	Alejo J. Nevado-Holgado, Elena Ribe, Laura Thei, Laura Furlong, Miguel-Angel Mayer, Jie Quan, Jill C. Richardson, Jonathan Cavanagh, NIMA Consortium, Simon Lovestone
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2019-05-01
Series:	Cells
Assuntos:	Alzheimer JAK-STAT multimodal genomics transcriptomics animal models
Acceso en liña:	https://www.mdpi.com/2073-4409/8/5/425
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