FGF2-FGFR1 signaling regulates release of Leukemia-Protective exosomes from bone marrow stromal cells

Protective signaling from the leukemia microenvironment leads to leukemia cell persistence, development of resistance, and disease relapse. Here, we demonstrate that fibroblast growth factor 2 (FGF2) from bone marrow stromal cells is secreted in exosomes, which are subsequently endocytosed by leukem...

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Bibliografiske detaljer

Principais autores:	Nathalie Javidi-Sharifi, Jacqueline Martinez, Isabel English, Sunil K Joshi, Renata Scopim-Ribeiro, Shelton K Viola, David K Edwards V, Anupriya Agarwal, Claudia Lopez, Danielle Jorgens, Jeffrey W Tyner, Brian J Druker, Elie Traer
Format:	Artigo
Sprog:	Inglês
Udgivet:	eLife Sciences Publications Ltd 2019-02-01
Serier:	eLife
Fag:	FGF2 FGFR1 exosomes bone marrow stroma microenvironment drug resistance
Online adgang:	https://elifesciences.org/articles/40033
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