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Role of Ca2+/Calmodulin-Dependent Protein Kinase Type II in Mediating Function and Dysfunction at Glutamatergic Synapses

Glutamatergic synapses harbor abundant amounts of the multifunctional Ca2+/calmodulin-dependent protein kinase type II (CaMKII). Both in the postsynaptic density as well as in the cytosolic compartment of postsynaptic terminals, CaMKII plays major roles. In addition to its Ca2+-stimulated kinase act...

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Principais autores: Archana G. Mohanan, Sowmya Gunasekaran, Reena Sarah Jacob, R. V. Omkumar
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-06-01
Serier:Frontiers in Molecular Neuroscience
Fag:
Ca2+/calmodulin-dependent protein kinase type II (CaMKII)
glutamatergic synapse
LTP
LTD
synaptic plasticity
CaMKII genetic models
Online adgang:https://www.frontiersin.org/articles/10.3389/fnmol.2022.855752/full
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