Innate and adaptive immune cell interaction drives inflammasome activation and hepatocyte apoptosis in murine liver injury from immune checkpoint inhibitors

Abstract Immune checkpoints (CTLA4 & PD-1) are inhibitory pathways that block aberrant immune activity and maintain self-tolerance. Tumors co-opt these checkpoints to avoid immune destruction. Immune checkpoint inhibitors (ICIs) activate immune cells and restore their tumoricidal potential, making t...

詳細記述

書誌詳細

主要な著者:	Layla Shojaie, Jacob M. Bogdanov, Helia Alavifard, Mahmoud G. Mohamed, Aria Baktash, Myra Ali, Simeon Mahov, Sue Murray, Gary C. Kanel, Zhang-Xu Liu, Fumito Ito, Gino K. In, Akil Merchant, William Stohl, Lily Dara
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Publishing Group 2024-02-01
シリーズ:	Cell Death and Disease
オンライン･アクセス:	https://doi.org/10.1038/s41419-024-06535-7
タグ:	タグ追加 タグなし, このレコードへの初めてのタグを付けませんか!