Adeno-associated viral vector serotype 5 poorly transduces liver in rat models.

Preclinical studies in mice and non-human primates showed that AAV serotype 5 provides efficient liver transduction and as such seems a promising vector for liver directed gene therapy. An advantage of AAV5 compared to serotype 8 already shown to provide efficient correction in a phase 1 trial in pa...

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Hauptverfasser:	Paula S Montenegro-Miranda, Astrid Pañeda, Lysbeth ten Bloemendaal, Suzanne Duijst, Dirk R de Waart, Gloria Gonzalez- Aseguinolaza, Piter J Bosma
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Public Library of Science (PLoS) 2013-01-01
Schriftenreihe:	PLoS ONE
Online-Zugang:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0082597&type=printable
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