Zinc transporter 8 haploinsufficiency protects against beta cell dysfunction in type 1 diabetes by increasing mitochondrial respiration

Objective: Zinc transporter 8 (ZnT8) is a major humoral target in human type 1 diabetes (T1D). Polymorphic variants of Slc30A8, which encodes ZnT8, are also associated with protection from type 2 diabetes (T2D). The current study examined whether ZnT8 might play a role beyond simply being a target o...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Yong Kyung Kim, Jay A. Walters, Nicole D. Moss, Kristen L. Wells, Ryan Sheridan, Jose G. Miranda, Richard K.P. Benninger, Laura L. Pyle, Richard M. O'Brien, Lori Sussel, Howard W. Davidson
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2022-12-01
coleção:	Molecular Metabolism
Assuntos:	Type 1 diabetes Zinc transporter 8 Mitochondria NOD mouse Islets of langerhans
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2212877822002010
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!