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Increased lethality in influenza and SARS-CoV-2 coinfection is prevented by influenza immunity but not SARS-CoV-2 immunity

Influenza A virus (IAV) and SARS-CoV-2 coinfection is a possible scenario during influenza season. Here, the authors show in a mouse model that IAV infection increases the risk of severe disease upon SARS-CoV-2 infection two days later. IAV vaccination, especially antibody-dependent, protects from s...

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Main Authors: Hagit Achdout, Einat. B. Vitner, Boaz Politi, Sharon Melamed, Yfat Yahalom-Ronen, Hadas Tamir, Noam Erez, Roy Avraham, Shay Weiss, Lilach Cherry, Erez Bar-Haim, Efi Makdasi, David Gur, Moshe Aftalion, Theodor Chitlaru, Yaron Vagima, Nir Paran, Tomer Israely
Format: Artigo
Language:Inglês
Published: Nature Portfolio 2021-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-26113-1
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