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Database screening as a strategy to identify endogenous candidate metabolites to probe and assess mitochondrial drug toxicity

Abstract Adverse drug reactions (ADRs) are considered an inherent risk of medication use, and some ADRs have been associated with off-target drug interactions with mitochondria. Metabolites that reflect mitochondrial function may help identify patients at risk of mitochondrial toxicity. We employed...

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Principais autores: Mery Vet George De la Rosa, Dipali Patel, Marc R. McCann, Kathleen A. Stringer, Gus R. Rosania
Formato: Artigo
Idioma:Inglês
Publicado: Nature Portfolio 2023-12-01
Series:Scientific Reports
Acceso en liña:https://doi.org/10.1038/s41598-023-49443-0
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