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Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network

Abstract Background Mutations in amyloid precursor protein (APP), presenilin 1 (PSEN1) and presenilin 2 (PSEN2) cause autosomal dominant forms of Alzheimer disease (ADAD). More than 280 pathogenic mutations have been reported in APP, PSEN1, and PSEN2. However, understanding of the basic biological m...

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Autors principals: Celeste M. Karch, Damián Hernández, Jen-Chyong Wang, Jacob Marsh, Alex W. Hewitt, Simon Hsu, Joanne Norton, Denise Levitch, Tamara Donahue, Wendy Sigurdson, Bernardino Ghetti, Martin Farlow, Jasmeer Chhatwal, Sarah Berman, Carlos Cruchaga, John C. Morris, Randall J. Bateman, the Dominantly Inherited Alzheimer Network (DIAN), Alice Pébay, Alison M. Goate
Format: Artigo
Idioma:Inglês
Publicat: BMC 2018-07-01
Col·lecció:Alzheimer’s Research & Therapy
Matèries:
Dominantly Inherited Alzheimer Network
Amyloid precursor protein
Presenilin 1
Presenilin 2
Fibroblasts
Induced pluripotent stem cells
Accés en línia:http://link.springer.com/article/10.1186/s13195-018-0400-0
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