Epoxy fatty acids and inhibition of the soluble epoxide hydrolase selectively modulate GABA mediated neurotransmission to delay onset of seizures.

In the brain, seizures lead to release of large amounts of polyunsaturated fatty acids including arachidonic acid (ARA). ARA is a substrate for three major enzymatic routes of metabolism by cyclooxygenase, lipoxygenase and cytochrome P450 enzymes. These enzymes convert ARA to potent lipid mediators...

وصف كامل

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Bora Inceoglu, Dorota Zolkowska, Hyun Ju Yoo, Karen M Wagner, Jun Yang, Edward Hackett, Sung Hee Hwang, Kin Sing Stephen Lee, Michael A Rogawski, Christophe Morisseau, Bruce D Hammock
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Public Library of Science (PLoS) 2013-01-01
سلاسل:	PLoS ONE
الوصول للمادة أونلاين:	http://europepmc.org/articles/PMC3862847?pdf=render
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!