Fiber mediated receptor masking in non-infected bystander cells restricts adenovirus cell killing effect but promotes adenovirus host co-existence.

The basic concept of conditionally replicating adenoviruses (CRAD) as oncolytic agents is that progenies generated from each round of infection will disperse, infect and kill new cancer cells. However, CRAD has only inhibited, but not eradicated tumor growth in xenograft tumor therapy, and CRAD ther...

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Detalhes bibliográficos

Principais autores:	Johan Rebetz, Manli Na, Changqing Su, Bo Holmqvist, Anna Edqvist, Cecilia Nyberg, Bengt Widegren, Leif G Salford, Hans Olov Sjögren, Niklas Arnberg, Qijun Qian, Xiaolong Fan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2009-12-01
coleção:	PLoS ONE
Acesso em linha:	http://europepmc.org/articles/PMC2793518?pdf=render
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