Porphromonas gingivalis infection induces gingipain-dependent changes in the brain vasculature of zebrafish larvae

Abstract Recent studies link infections with blood–brain barrier (BBB) dysfunctions, neuroinflammation and subsequent neurodegeneration. Here, we employed a zebrafish larval model to study the impact of systemic infection with an oral pathogen Porphyromonas gingivalis (Pg) and its major virulence fa...

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Váldodahkkit:	Anna Mieszkowska, Magdalena Marcinkowska, Magdalena Widziolek, Jan Potempa, Magdalena Chadzinska
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	BMC 2025-11-01
Ráidu:	Cell Communication and Signaling
Fáttát:	Brain-blood barrier permeability Tight junction proteins Porphyromonas gingivalis Gingipains Zebrafish larvae
Liŋkkat:	https://doi.org/10.1186/s12964-025-02557-6
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