Evolving prion-like tau conformers differentially alter postsynaptic proteins in neurons inoculated with distinct isolates of Alzheimer’s disease tau

Abstract Objectives Although accumulation of misfolded tau species has been shown to predict cognitive decline in patients with Alzheimer’s disease (AD) and other tauopathies but with the remarkable diversity of clinical manifestations, neuropathology profiles, and time courses of disease progressio...

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Detalhes bibliográficos

Principais autores:	Lenka Hromadkova, Chae Kim, Tracy Haldiman, Lihua Peng, Xiongwei Zhu, Mark Cohen, Rohan de Silva, Jiri G. Safar
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2023-09-01
coleção:	Cell & Bioscience
Assuntos:	Alzheimer’s disease Conformational diversity Postsynaptic scaffolding proteins Propagation of tau aggregation Synapses loss Tau misfolding
Acesso em linha:	https://doi.org/10.1186/s13578-023-01133-0
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