Selective Stability Indicating Liquid Chromatographic Method Based on Quality by Design Framework and In Silico Toxicity Assessment for Infigratinib and Its Degradation Products

Infigratinib, a protein kinase inhibitor employed in the therapeutic management of cholangiocarcinoma, was subjected to various stress conditions, including hydrolytic (acidic and alkaline), oxidative, photolytic, and thermal stress, in accordance with the rules established by the International Coun...

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Hauptverfasser:	Awadh M. Ali, Mohammed M. Alanazi, Mohamed W. Attwa, Hany W. Darwish
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2023-11-01
Schriftenreihe:	Molecules
Schlagworte:	Infigratinib forced stress degradation stability-indicating analytical methods degradation products quality-by-design LC-MS/MS
Online-Zugang:	https://www.mdpi.com/1420-3049/28/22/7476
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