Oxygen enhances antiviral innate immunity through maintenance of EGLN1-catalyzed proline hydroxylation of IRF3

Abstract Oxygen is essential for aerobic organisms, but little is known about its role in antiviral immunity. Here, we report that during responses to viral infection, hypoxic conditions repress antiviral-responsive genes independently of HIF signaling. EGLN1 is identified as a key mediator of the o...

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Hlavní autoři:	Xing Liu, Jinhua Tang, Zixuan Wang, Chunchun Zhu, Hongyan Deng, Xueyi Sun, Guangqing Yu, Fangjing Rong, Xiaoyun Chen, Qian Liao, Shuke Jia, Wen Liu, Huangyuan Zha, Sijia Fan, Xiaolian Cai, Jian-Fang Gui, Wuhan Xiao
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2024-04-01
Edice:	Nature Communications
On-line přístup:	https://doi.org/10.1038/s41467-024-47814-3
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