Fluconazole plus flucytosine versus fluconazole alone for adults with HIV-associated cryptococcal antigenaemia identified through screening: a multi-centre phase III randomised-controlled trial

Abstract Background Despite the expansion of antiretroviral treatment programmes, the incidence and mortality of HIV-associated cryptococcal meningitis remain high in Africa. Cryptococcal antigen (CrAg) in the blood precedes meningitis. CrAg screening of individuals with advanced HIV disease, combin...

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Principais autores:	Kyla Murphy, Jeremy S. Nel, Mahomed-Yunus Moosa, Douglas P. Wilson, Merika Tsitsi, Sayoki Mfinanga, Sokoine Kivuyo, Denise Kyazze, Nowshad Alam, Graeme Meintjes, Michelle Eriksson, Jack Adams, Colin Menezes, Ebrahim Variava, John Black, Marise Bremer, Vu Quoc Dat, Thuy Le, Charlotte Schutz, Angela Loyse, Rachel M. Wake, David S. Lawrence, Duolao Wang, Shabbar Jaffar, Joseph N. Jarvis, Thomas S. Harrison, Síle F. Molloy, Nelesh P. Govender
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-03-01
coleção:	Trials
Assuntos:	Human immunodeficiency virus (HIV) Advanced HIV disease (AHD) Cryptococcosis Cryptococcal antigen (CrAg) Cryptococcal meningitis (CM) Fluconazole
Acesso em linha:	https://doi.org/10.1186/s13063-026-09520-x
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