A Cre-dependent massively parallel reporter assay allows for cell-type specific assessment of the functional effects of non-coding elements in vivo

Abstract The function of regulatory elements is highly dependent on the cellular context, and thus for understanding the function of elements associated with psychiatric diseases these would ideally be studied in neurons in a living brain. Massively Parallel Reporter Assays (MPRAs) are molecular gen...

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Principais autores:	Tomas Lagunas, Stephen P. Plassmeyer, Anthony D. Fischer, Ryan Z. Friedman, Michael A. Rieger, Din Selmanovic, Simona Sarafinovska, Yvette K. Sol, Michael J. Kasper, Stuart B. Fass, Alessandra F. Aguilar Lucero, Joon-Yong An, Stephan J. Sanders, Barak A. Cohen, Joseph D. Dougherty
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2023-11-01
coleção:	Communications Biology
Acesso em linha:	https://doi.org/10.1038/s42003-023-05483-w
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