Blockade of NKp46⁻ CCR6⁻ ILC3 autophagy protects against necrotizing enterocolitis by restoring energy metabolism balance in mice

Abstract Group 3 innate lymphoid cells (ILC3) are crucial in neonatal necrotizing enterocolitis (NEC); however, the underlying mechanisms remain elusive. Here, we identify NKp46⁻CCR6⁻ (double-negative, DN) ILC3s as the dominant pathogenic subset driving NEC via IL-17 A secretion, which disrupts inte...

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Autors principals:	Junyu He, Meiqi Chen, Laiqin Peng, Qiqiong Wang, Yizhuang Lu, Yimin Chen, Xinyao Li, Yanling Mou, Jianjun Wang, Yuxiong Guo, Kai Wu, Yumei He
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2026-05-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-026-73356-x
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