Axon demyelination and degeneration in a zebrafish spastizin model of hereditary spastic paraplegia

Hereditary spastic paraplegias (HSPs) are a diverse set of neurological disorders characterized by progressive spasticity and weakness in the lower limbs caused by damage to the axons of the corticospinal tract. More than 88 genetic mutations have been associated with HSP, yet the mechanisms underly...

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Autori principali:	Vranda Garg, Selina André, Luisa Heyer, Gudrun Kracht, Torben Ruhwedel, Patricia Scholz, Till Ischebeck, Hauke B. Werner, Christian Dullin, Jacob Engelmann, Wiebke Möbius, Martin C. Göpfert, Roland Dosch, Bart R. H. Geurten
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	The Royal Society 2024-11-01
Serie:	Open Biology
Soggetti:	Hereditary spastic paraplegia (HSP) spastizin zebrafish lower limb spasticity mauthner neurons C-start escape response
Accesso online:	https://royalsocietypublishing.org/doi/10.1098/rsob.240100
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