Gasdermin D promotes influenza virus-induced mortality through neutrophil amplification of inflammation

Abstract Influenza virus activates cellular inflammasome pathways, which can be both beneficial and detrimental to infection outcomes. Here, we investigate the function of the inflammasome-activated, pore-forming protein gasdermin D (GSDMD) during infection. Ablation of GSDMD in knockout (KO) mice (...

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Autors principals:	Samuel Speaks, Matthew I. McFadden, Ashley Zani, Abigail Solstad, Steve Leumi, Jack E. Roettger, Adam D. Kenney, Hannah Bone, Lizhi Zhang, Parker J. Denz, Adrian C. Eddy, Amal O. Amer, Richard T. Robinson, Chuanxi Cai, Jianjie Ma, Emily A. Hemann, Adriana Forero, Jacob S. Yount
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2024-03-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-024-47067-0
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