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MyD88-dependent signaling drives toll-like receptor-induced trained immunity in macrophages

Immunocompromised populations are highly vulnerable to developing life-threatening infections. Strategies to protect patients with weak immune responses are urgently needed. Employing trained immunity, whereby innate leukocytes undergo reprogramming upon exposure to a microbial product and respond m...

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Principais autores: Allison M. Owen, Liming Luan, Katherine R. Burelbach, Margaret A. McBride, Cody L. Stothers, Olivia A. Boykin, Kalkena Sivanesam, Jessica F. Schaedel, Tazeen K. Patil, Jingbin Wang, Antonio Hernandez, Naeem K. Patil, Edward R. Sherwood, Julia K. Bohannon
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-11-01
coleção:Frontiers in Immunology
Assuntos:
toll-like receptor (TLR)
TLR4
innate immunity
trained immunity
macrophage
metabolic reprogramming
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1044662/full
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