4-Phenylbutyrate mitigates renal pathology linked to ER stress related pathways in C57BL/6J mice with hindlimb unloading

Abstract 4-Phenylbutyrate (4-PBA), a chemical chaperone known to reduce endoplasmic reticulum (ER) stress—a key contributor to kidney injury and fibrosis—has shown therapeutic potential in various disease models. However, the impact of hindlimb unloading (HU) on renal ER stress and its transcriptomi...

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Κύριοι συγγραφείς:	Anu Vinod Ranade, Grisilda Vidya Bernhardt, Josemin Jose, Gopika Ramachandran, Suni Ebby, Asima Karim, Firdos Ahmad, Rizwan Qaisar, K. M. Damodara Gowda
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Nature Portfolio 2026-04-01
Σειρά:	Scientific Reports
Θέματα:	Endoplasmic reticulum stress Kidneys Hindlimb-unloaded mice Protein dysregulation Microgravity
Διαθέσιμο Online:	https://doi.org/10.1038/s41598-026-47754-6
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