Chaperone-Mediated Protein Disaggregation Triggers Proteolytic Clearance of Intra-nuclear Protein Inclusions

Summary: The formation of insoluble inclusions in the cytosol and nucleus is associated with impaired protein homeostasis and is a hallmark of several neurodegenerative diseases. Due to the absence of the autophagic machinery, nuclear protein aggregates require a solubilization step preceding degrad...

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Autores principales:	Fabian den Brave, Lucas V. Cairo, Chandhuru Jagadeesan, Carmen Ruger-Herreros, Axel Mogk, Bernd Bukau, Stefan Jentsch
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2020-06-01
Colección:	Cell Reports
Materias:	Proteostasis Chaperone Disaggregation protein degradation nucleus Apj1
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S2211124720306331
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