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Tadalafil-Loaded Self-Nanoemulsifying Chewable Tablets for Improved Bioavailability: Design, In Vitro, and In Vivo Testing

This research aimed to develop innovative self-nanoemulsifying chewable tablets (SNECT) to increase oral bioavailability of tadalafil (TDL), a nearly insoluble phosphodiesterase-5 inhibitor. Cinnamon essential oil, PEG 40 hydrogenated castor oil (Cremophor<sup>®</sup> RH 40), and polyethylene glycol...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Hany S. M. Ali, Sameh A. Ahmed, Abdulmalik A. Alqurshi, Ali M. Alalawi, Ahmed M. Shehata, Yaser M. Alahmadi
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2022-09-01
Schriftenreihe:Pharmaceutics
Schlagworte:
tadalafil
self-nanoemulsifying
solidification
chewable tablets
bioavailability
Online-Zugang:https://www.mdpi.com/1999-4923/14/9/1927
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