The spatial impact of a Western diet in enriching Galectin-1-regulated Rho, ECM, and SASP signaling in a novel MASH-HCC mouse model

Abstract Background Hepatocellular carcinoma (HCC) arising from metabolic dysfunction-associated steatohepatitis (MASH) presents a significant clinical challenge, particularly given the prevalence of the Western diet (WD). The influence of diet on the tumor microenvironment remains poorly understood...

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Detalhes bibliográficos

Principais autores:	Tahereh Setayesh, Ying Hu, Farzam Vaziri, Dongguang Wei, Yu-Jui Yvonne Wan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-10-01
coleção:	Biomarker Research
Assuntos:	Hepatocellular carcinoma Metabolic-associated fatty liver disease Epithelial-to-mesenchymal transition Extracellular matrix remodeling, and senescence-associated secretory phenotypes
Acesso em linha:	https://doi.org/10.1186/s40364-024-00660-3
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