Appraisal of anti-protozoan activity of nitroaromatic benzenesulfonamides inhibiting carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani

Chagas disease and leishmaniasis are neglected tropical disorders caused by the protozoans Trypanosoma cruzi and Leishmania spp. Carbonic anhydrases (CAs, EC 4.2.1.1) from these protozoans (α-TcCA and β-LdcCA) have been validated as promising targets for chemotherapic interventions. Many anti-protoz...

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Autors principals:	Alessio Nocentini, Sameh M. Osman, Igor A. Rodrigues, Veronica S. Cardoso, Fatmah Ali S. Alasmary, Zeid AlOthman, Alane B. Vermelho, Paola Gratteri, Claudiu T. Supuran
Format:	Artigo
Idioma:	Inglês
Publicat:	Taylor & Francis Group 2019-01-01
Col·lecció:	Journal of Enzyme Inhibition and Medicinal Chemistry
Matèries:	carbonic anhydrase chagas disease leishmania trypanosoma nitroaromatics
Accés en línia:	http://dx.doi.org/10.1080/14756366.2019.1626375
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