TLR7 agonist, N6-LS and PGT121 delayed viral rebound in SHIV-infected macaques after antiretroviral therapy interruption.

Toll-like receptor 7 (TLR7) agonist and PGT121 (broadly neutralizing antibody, bnAb) administration previously delayed viral rebound and induced SHIV remission. We evaluated the impact of GS-986 (TLR7 agonist) and dual bnAbs on viral rebound after antiretroviral therapy (ART) interruption. Rhesus ma...

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Detaylı Bibliyografya
Asıl Yazarlar:	Denise C Hsu, Alexandra Schuetz, Rawiwan Imerbsin, Decha Silsorn, Amarendra Pegu, Dutsadee Inthawong, Jumpol Sopanaporn, Pornsuk Visudhiphan, Weerawan Chuenarom, Boot Keawboon, Wei Shi, Merlin L Robb, John R Mascola, Romas Geleziunas, Richard A Koup, Dan H Barouch, Nelson L Michael, Sandhya Vasan
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	Public Library of Science (PLoS) 2021-02-01
Seri Bilgileri:	PLoS Pathogens
Online Erişim:	https://doi.org/10.1371/journal.ppat.1009339
Etiketler:	Etiketle Etiket eklenmemiş, İlk siz ekleyin!

TLR7 agonist, N6-LS and PGT121 delayed viral rebound in SHIV-infected macaques after antiretroviral therapy interruption.

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