Multiphasic blood transcriptomic signatures of radioprotection by BIO 300, a synthetic genistein nanosuspension, in a nonhuman primate model of acute radiation syndrome

Abstract Background Prophylactic radioprotectors for pre-exposure administration are notably absent, creating a critical gap in radiation emergency preparedness and ARS management. BIO 300, a wet-nanomilled formulation of synthetic genistein, is in advanced development as a prophylactic radioprotect...

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Principais autores:	Neetha Nanoth Vellichirammal, Stephen Y. Wise, Oluseyi O. Fatanmi, Rachel C. Mingus, Alana D. Carpenter, Sarah A. Petrus, Michael D. Kaytor, Vijay K. Singh
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-06-01
coleção:	Journal of Translational Medicine
Assuntos:	BIO 300 Transcriptomics Temporal change Acute radiation syndrome Medical countermeasures Radioprotection
Acesso em linha:	https://doi.org/10.1186/s12967-026-08485-4
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