Exploring the role of APRIL in autoimmunity: implications for therapeutic targeting in systemic lupus erythematosus, rheumatoid arthritis, and Sjögren’s syndrome

Autoimmunity arises when the immune system erroneously attacks self-antigens, potentially resulting in organ dysfunction. This review focuses on the proliferation-inducing ligand, APRIL, and its critical role in regulating antibody-producing B cells. We explore the implications of APRIL in autoimmun...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Anastasia V. Poznyak, Elena V. Gerasimova, Nikolay A. Orekhov, Amina Eldarovna Karimova, Maria Andreevna Vergun, Ksenia Olegovna Lapshina, Vasily N. Sukhorukov, Alexander N. Orekhov
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-08-01
coleção:	Frontiers in Immunology
Assuntos:	APRIL (TNFSF13) BAFF B cells autoimmunity rheumatoid arthritis
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1523392/full
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!