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Nanomedicine Against Aβ Aggregation by β–Sheet Breaker Peptide Delivery: In Vitro Evidence

The accumulation of amyloid β (Aβ) triggers a cascade of toxic events in Alzheimer’s disease (AD). The KLVFF peptide can interfere with Aβ aggregation. However, the peptide suffers from poor bioavailability and the inability to cross the blood−brain barrier. In this work,...

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Автори: Francesca Pederzoli, Barbara Ruozi, Jason Duskey, Simone Hagmeyer, Ann Katrin Sauer, Stefanie Grabrucker, Romina Coelho, Natalia Oddone, Ilaria Ottonelli, Eleonora Daini, Michele Zoli, Maria Angela Vandelli, Giovanni Tosi, Andreas M. Grabrucker
Формат: Artigo
Мова:Inglês
Опубліковано: MDPI AG 2019-11-01
Серія:Pharmaceutics
Предмети:
alzheimer disease (ad)
polymeric nanoparticles (nps)
klvff peptide
blood-brain barrier (bbb)
amyloid β
aβ
Онлайн доступ:https://www.mdpi.com/1999-4923/11/11/572
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