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Hexokinase controls platelet activation and hemostasis

Platelet activation is energy-dependent and associated with a hyperglycolytic phenotype, yet the role of key glycolytic enzymes remains unclear. We investigated the role of platelet hexokinases (HK1 and HK2) in regulating thrombin- and convulxin-stimulated bioenergetics, functions, and hemostasis us...

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Autori principali: Lih T. Cheah, Jawad S. Khalil, Beth A. Webb, Daisie M. Yates, Reem Alotaibi, Mary McKay, Mohammad Ali, Thomas Palmer-Dench, Emily Horner, Mugthalana Allet, Fraser Macrae, Cedric Duval, Amanda J. Unsworth, Mark T. Kearney, Khalid M. Naseem
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis Group 2026-06-01
Serie:Platelets
Soggetti:
Hemostasis
hexokinase
metabolic reprogramming
platelet activation
Accesso online:https://www.tandfonline.com/doi/10.1080/09537104.2026.2692723
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