Immortalized mammosphere-derived epithelial cells retain a bioactive secretome with antimicrobial, regenerative, and immunomodulatory properties

Abstract Background The secretome of primary bovine mammosphere-derived epithelial cells (MDECs) has been shown to exert antimicrobial, regenerative, and immunomodulatory properties in vitro, which warrants its study as a potential biologic treatment with the potential to be translated to human medi...

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Bibliografische Detailangaben

Hauptverfasser:	Nikola Danev, Julia M. Poggi, Emilie A. Dewever, Arianna P. Bartlett, Leane Oliveira, Lucas Huntimer, Rebecca M. Harman, Gerlinde R. Van de Walle
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2024-11-01
Schriftenreihe:	Stem Cell Research & Therapy
Schlagworte:	Mammary epithelial cells Secretome Immortalization Immunomodulation Antimicrobial effects Fibroblast migration
Online-Zugang:	https://doi.org/10.1186/s13287-024-04019-1
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