Structural insights into distinct filamentation states reveal a regulatory mechanism for bacterial STING activation

ABSTRACT The cyclic oligonucleotide-based antiphage signaling system (CBASS) is a bacterial immune mechanism that was evolutionarily linked to the eukaryotic cGAS–STING pathway, which protects against phage infection through abortive cell death. CBASS operons encode cyclic dinucleotide synthases (CD...

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Auteurs principaux:	Yuchao Yang, Yueyue Liu, Xue Ma, Xuan Zhao, Jian Cao, Yu Liu, Shanqin Li, Jing Wu, Yuanzhu Gao, Lianwan Chen, Changxin Wu, Guijun Shang, Sheng Liu, Defen Lu
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology 2025-09-01
Collection:	mBio
Sujets:	TIR-STING 3′3′-c-di-GMP filament CBASS CD-NTases Cap proteins
Accès en ligne:	https://journals.asm.org/doi/10.1128/mbio.00388-25
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