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Design and Development of D‒α‒Tocopheryl Polyethylene Glycol Succinate‒<i>block</i>‒Poly(ε-Caprolactone) (TPGS−<i>b</i>−PCL) Nanocarriers for Solubilization and Controlled Release of Paclitaxel

The objective of this study was to synthesize and characterize a set of biodegradable block copolymers based on TPGS-<i>block</i>-poly(ε-caprolactone) (TPGS-<i>b</i>-PCL) and to assess their self-assembled structures as a nanodelivery system for paclitaxel (PAX). The conjugation of PCL to TPGS was h...

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Principais autores: Osman Yusuf, Raisuddin Ali, Abdullah H. Alomrani, Aws Alshamsan, Abdullah K. Alshememry, Abdulaziz M. Almalik, Afsaneh Lavasanifar, Ziyad Binkhathlan
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-05-01
Serier:Molecules
Fag:
D‒α‒tocopheryl polyethylene glycol succinate
block copolymer
nanocarriers
polymeric micelles
paclitaxel
Online adgang:https://www.mdpi.com/1420-3049/26/9/2690
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