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Obestatin stimulates glucose-induced insulin secretion through ghrelin receptor GHS-R

Abstract Orexigenic hormone ghrelin and anorexic hormone obestatin are encoded by the same preproghrelin gene. While it is known that ghrelin inhibits glucose-stimulated insulin secretion (GSIS), the effect of obestatin on GSIS is unclear. Ghrelin’s effect is mediated by its receptor Growth Hormone...

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Autores principales: Geetali Pradhan, Chia-Shan Wu, Jong Han Lee, Preeti Kanikarla, Shaodong Guo, Vijay K. Yechoor, Susan L. Samson, Yuxiang Sun
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Portfolio 2017-04-01
Colección:Scientific Reports
Acceso en línea:https://doi.org/10.1038/s41598-017-00888-0
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