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Targeting PIP5K ameliorates hepatic cancer by inhibiting PI3K/AKT and the autophagy mechanism and enhancing ROS-mediated apoptosis

IntroductionHepatic cancer cells regulate reactive oxygen species (ROS) and lipid kinases to promote proliferation and survival. The role of phosphatidylinositol-4-phosphate-5-kinase (PIP5K) in modulating the autophagy–Nrf2 antioxidant pathway remains unclear. In this study, we investigated the impa...

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Principais autores: P. A. Shantanu, Bishal Rajdev, N. P. Syamprasad, Jagadeesh Kumar Gangasani, Arijit Mandal, Samir Ranjan Panda, Ramakrishna Sistla, Sai Balaji Andugulapati, Shiv Kumar Sarin, Dinesh Mani Tripathi, V. G. M. Naidu
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-05-01
Serier:Frontiers in Pharmacology
Fag:
autophagy
hepatocellular carcinoma
Nrf2
phosphatidylinositol-4-phosphate-5-kinase
proliferation
reactive oxygen species
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2026.1791462/full
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