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REC protein family expansion by the emergence of a new signaling pathway

ABSTRACTThis report presents multi-genome evidence that REC protein family expansion occurs when the emergence of new pathways gives rise to functional discordance. Specificity between residues in REC domain containing response regulators with paired histidine kinases is under negative purifying sel...

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Principais autores: Megan E. Garber, Vered Frank, Alexey E. Kazakov, Matthew R. Incha, Alberto A. Nava, Hanqiao Zhang, Luis E. Valencia, Jay D. Keasling, Lara Rajeev, Aindrila Mukhopadhyay
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2023-12-01
coleção:mBio
Assuntos:
large protein families
two-component regulatory systems
evolution
gene regulation
genetic recombination
domain swapping
Acesso em linha:https://journals.asm.org/doi/10.1128/mbio.02622-23
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