Synthesis, Physicochemical Characterization, In Vitro 2D/3D Human Cell Culture, and In Vitro Aerosol Dispersion Performance of Advanced Spray Dried and Co-Spray Dried Angiotensin (1—7) Peptide and PNA5 with Trehalose as Microparticles/Nanoparticles for Targeted Respiratory Delivery as Dry Powder Inhalers

The peptide hormone Angiotensin (1—7), Ang (1—7) or (Asp-Arg-Val-Tyr-Ile-His-Pro), is an essential component of the renin–angiotensin system (RAS) peripherally and is an agonist of the Mas receptor centrally. Activation of this receptor in the CNS stimulates various biological activities that make t...

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Principais autores:	Wafaa Alabsi, Maria F. Acosta, Fahad A. Al-Obeidi, Meredith Hay, Robin Polt, Heidi M. Mansour
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2021-08-01
coleção:	Pharmaceutics
Assuntos:	solid phase peptide synthesis SPPS angiotensin glycopeptide brain in vitro 2D/3D cell culture
Acesso em linha:	https://www.mdpi.com/1999-4923/13/8/1278
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