Cancer Cell Metabolism Bolsters Immunotherapy Resistance by Promoting an Immunosuppressive Tumor Microenvironment

Immune checkpoint inhibitors (ICIs) targeting immune checkpoint proteins, such as CTLA-4 and PD-1/PD-L1, have demonstrated remarkable and durable clinical responses in various cancer types. However, a considerable number of patients receiving ICIs eventually experience a relapse due to diverse resis...

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Principais autores:	Zhou Jiang, Jennifer L. Hsu, Yintao Li, Gabriel N. Hortobagyi, Mien-Chie Hung
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2020-07-01
coleção:	Frontiers in Oncology
Assuntos:	immune checkpoint inhibitors cancer metabolism tumor microenvironment immune evasion cancer cell metabolite
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fonc.2020.01197/full
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